CSF1R(FMS)
Sign in to save this workspaceUniProt P07333 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: cytoplasmic
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Dasatinib | 98.8% | 1.2% | 87.97 | 0.699 |
| 2 | Ponatinib | 98.7% | 1.3% | 78.23 | 0.534 |
| 3 | Infigratinib | 98.7% | 1.3% | 98.24 | 0.710 |
| 4 | Tivozanib | 98.6% | 1.4% | 92.42 | 0.673 |
| 5 | Sorafenib | 98.1% | 1.9% | 96.72 | 0.776 |
| 6 | Apatinib | 97.8% | 2.2% | 97.73 | 0.704 |
| 7 | Erdafitinib | 97.6% | 2.4% | 95.71 | 0.737 |
| 8 | Pexidartinib | 97.5% | 2.5% | 99.49 | 0.631 |
| 9 | Regorafenib | 97.4% | 2.6% | 95.99 | 0.719 |
| 10 | Midostaurin | 97.3% | 2.7% | 78.64 | 0.500 |
| 11 | Ripretinib | 97.2% | 2.9% | 92.95 | 0.674 |
| 12 | Sunitinib | 97.1% | 2.9% | 91.73 | 0.524 |
| 13 | Avapritinib | 95.9% | 4.1% | 97.73 | 0.644 |
| 14 | Pacritinib | 95.7% | 4.3% | 88.64 | 0.452 |
| 15 | Pemigatinib | 95.5% | 4.5% | 98.23 | 0.718 |
| 16 | Nintedanib | 95.4% | 4.6% | 90.23 | 0.608 |
| 17 | Axitinib | 95.2% | 4.8% | 93.23 | 0.688 |
| 18 | Entrectinib | 93.5% | 6.5% | 93.69 | 0.671 |
| 19 | Pazopanib | 93.0% | 7.0% | 97.49 | 0.672 |
| 20 | Selpercatinib | 92.8% | 7.2% | 96.72 | 0.635 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.04
- Epithelial log2(TPM+1): 0.40
- Fold change: 0.64
- Status: No significant change
Selectivity landscape vs inhibition on CSF1R
Each point is one of the 92 approved drugs; color = inhibition % on CSF1R.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…