GSK3B(GSK3b)
Sign in to save this workspaceUniProt P49841 · PDB · AlphaFold · Substrate: Phospho-Glycogen Synthase peptide · Clone: full-lengthhigh-confidence target
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 96.5% | 3.5% | 91.48 | 0.563 |
| 2 | Defactinib | 96.3% | 3.7% | 92.68 | 0.450 |
| 3 | Encorafenib | 91.5% | 8.5% | 98.50 | 0.755 |
| 4 | Midostaurin | 78.4% | 21.6% | 78.64 | 0.500 |
| 5 | Deucravacitinib | 75.0% | 25.0% | 98.99 | 0.718 |
| 6 | Pacritinib | 70.7% | 29.3% | 88.64 | 0.452 |
| 7 | Vemurafenib | 59.9% | 40.1% | 96.49 | 0.598 |
| 8 | Neratinib | 56.5% | 43.5% | 93.18 | 0.597 |
| 9 | Pralsetinib | 49.2% | 50.8% | 93.43 | 0.643 |
| 10 | Nintedanib | 45.9% | 54.1% | 90.23 | 0.608 |
| 11 | Darovasertib | 36.8% | 63.2% | 96.99 | 0.719 |
| 12 | Fostamatinib | 23.7% | 76.3% | 96.74 | 0.613 |
| 13 | Dabrafenib | 23.2% | 76.8% | 94.74 | 0.633 |
| 14 | Selpercatinib | 22.6% | 77.4% | 96.72 | 0.635 |
| 15 | Baricitinib | 18.9% | 81.1% | 97.99 | 0.616 |
| 16 | Tepotinib | 18.7% | 81.3% | 99.75 | 0.727 |
| 17 | Pirtobrutinib | 16.3% | 83.7% | 99.49 | 0.656 |
| 18 | Canertinib | 16.1% | 83.9% | 96.49 | 0.671 |
| 19 | Regorafenib | 16.0% | 84.0% | 95.99 | 0.719 |
| 20 | Capmatinib | 15.1% | 84.9% | 99.75 | 0.582 |
Paralog block
GSK3A, GSK3B
EMT expression
- Mesenchymal log2(TPM+1): 5.09
- Epithelial log2(TPM+1): 4.81
- Fold change: 0.28
- Status: No significant change
High-confidence drugs
- Encorafenib — inh 91.5% · KISS 50.48
- Abemaciclib — inh 96.5% · KISS 33.59
- Deucravacitinib — inh 75.0% · KISS 31.75
Selectivity landscape vs inhibition on GSK3B
Each point is one of the 92 approved drugs; color = inhibition % on GSK3B.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (1)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| C199A | carcinoma_breast | Breast | ref |
| C199A | carcinoma_pancreas | Pancreas | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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