UniProt Q86Z02 · PDB · AlphaFold · Substrate: MBP · Clone: aa 158-555
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 83.6% | 16.4% | 91.48 | 0.563 |
| 2 | Pacritinib | 64.3% | 35.7% | 88.64 | 0.452 |
| 3 | Dabrafenib | 34.0% | 66.0% | 94.74 | 0.633 |
| 4 | Defactinib | 20.4% | 79.6% | 92.68 | 0.450 |
| 5 | Baricitinib | 15.1% | 84.9% | 97.99 | 0.616 |
| 6 | Binimetinib | 13.9% | 86.1% | 100.00 | 0.689 |
| 7 | Tofacitinib | 11.3% | 88.7% | 99.25 | 0.684 |
| 8 | Sunitinib | 9.8% | 90.2% | 91.73 | 0.524 |
| 9 | Capmatinib | 7.8% | 92.2% | 99.75 | 0.582 |
| 10 | Capivasertib | 7.7% | 92.3% | 96.48 | 0.644 |
| 11 | Palbociclib | 7.4% | 92.6% | 98.75 | 0.673 |
| 12 | Tivozanib | 7.3% | 92.7% | 92.42 | 0.673 |
| 13 | Gilteritinib | 5.3% | 94.7% | 88.97 | 0.506 |
| 14 | Repotrectinib | 5.2% | 94.8% | 84.21 | 0.608 |
| 15 | Abrocitinib | 5.1% | 94.9% | 99.50 | 0.581 |
| 16 | Fedratinib | 4.6% | 95.4% | 96.21 | 0.576 |
| 17 | Bosutinib | 3.9% | 96.1% | 87.22 | 0.555 |
| 18 | Pralsetinib | 3.9% | 96.1% | 93.43 | 0.643 |
| 19 | Lazertinib | 3.8% | 96.2% | 97.47 | 0.674 |
| 20 | Canertinib | 3.2% | 96.8% | 96.49 | 0.671 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.96
- Epithelial log2(TPM+1): 3.75
- Fold change: 0.20
- Status: No significant change
Selectivity landscape vs inhibition on HIPK1
Each point is one of the 92 approved drugs; color = inhibition % on HIPK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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