UniProt Q9H422 · PDB · AlphaFold · Substrate: MBP · Clone: aa 163-562
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 92.3% | 7.7% | 91.48 | 0.563 |
| 2 | Pacritinib | 76.9% | 23.1% | 88.64 | 0.452 |
| 3 | Defactinib | 38.9% | 61.1% | 92.68 | 0.450 |
| 4 | Sunitinib | 23.8% | 76.2% | 91.73 | 0.524 |
| 5 | Regorafenib | 23.1% | 76.9% | 95.99 | 0.719 |
| 6 | Dabrafenib | 20.4% | 79.6% | 94.74 | 0.633 |
| 7 | Sorafenib | 19.5% | 80.5% | 96.72 | 0.776 |
| 8 | Ponatinib | 18.9% | 81.1% | 78.23 | 0.534 |
| 9 | Ibrutinib | 16.0% | 84.0% | 94.74 | 0.723 |
| 10 | Bosutinib | 15.5% | 84.5% | 87.22 | 0.555 |
| 11 | Fostamatinib | 14.7% | 85.3% | 96.74 | 0.613 |
| 12 | Ribociclib | 12.9% | 87.1% | 99.25 | 0.729 |
| 13 | Capmatinib | 12.9% | 87.1% | 99.75 | 0.582 |
| 14 | Palbociclib | 11.7% | 88.3% | 98.75 | 0.673 |
| 15 | Trametinib | 10.8% | 89.2% | 99.50 | 0.718 |
| 16 | Imatinib | 10.3% | 89.7% | 99.00 | 0.718 |
| 17 | Remibrutinib | 10.1% | 89.9% | 99.50 | 0.721 |
| 18 | Tofacitinib | 9.6% | 90.4% | 99.25 | 0.684 |
| 19 | Quizartinib | 9.3% | 90.7% | 99.50 | 0.737 |
| 20 | Cabozantinib | 9.1% | 90.9% | 92.73 | 0.751 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.58
- Epithelial log2(TPM+1): 3.51
- Fold change: 0.07
- Status: No significant change
Selectivity landscape vs inhibition on HIPK3
Each point is one of the 92 approved drugs; color = inhibition % on HIPK3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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