MAPK8(JNK1)
Sign in to save this workspaceUniProt P45983-2 · PDB · AlphaFold · Substrate: ATF2 · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pacritinib | 88.5% | 11.5% | 88.64 | 0.452 |
| 2 | Ripretinib | 88.5% | 11.5% | 92.95 | 0.674 |
| 3 | Neratinib | 85.7% | 14.3% | 93.18 | 0.597 |
| 4 | Brigatinib | 81.8% | 18.2% | 82.96 | 0.513 |
| 5 | Fostamatinib | 74.7% | 25.3% | 96.74 | 0.613 |
| 6 | Gilteritinib | 73.9% | 26.1% | 88.97 | 0.506 |
| 7 | Vemurafenib | 73.8% | 26.2% | 96.49 | 0.598 |
| 8 | Encorafenib | 69.9% | 30.1% | 98.50 | 0.755 |
| 9 | Fedratinib | 67.8% | 32.1% | 96.21 | 0.576 |
| 10 | Abemaciclib | 64.8% | 35.2% | 91.48 | 0.563 |
| 11 | Pazopanib | 60.5% | 39.5% | 97.49 | 0.672 |
| 12 | Nilotinib | 57.6% | 42.4% | 96.49 | 0.765 |
| 13 | Umbralisib | 43.1% | 56.9% | 98.74 | 0.670 |
| 14 | Apatinib | 42.7% | 57.3% | 97.73 | 0.704 |
| 15 | Dabrafenib | 36.3% | 63.7% | 94.74 | 0.633 |
| 16 | Ceritinib | 30.6% | 69.4% | 95.44 | 0.618 |
| 17 | Defactinib | 28.0% | 72.0% | 92.68 | 0.450 |
| 18 | Midostaurin | 25.5% | 74.5% | 78.64 | 0.500 |
| 19 | Upadacitinib | 24.9% | 75.1% | 97.98 | 0.663 |
| 20 | Selpercatinib | 24.0% | 76.0% | 96.72 | 0.635 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.79
- Epithelial log2(TPM+1): 4.51
- Fold change: 0.28
- Status: No significant change
Selectivity landscape vs inhibition on MAPK8
Each point is one of the 92 approved drugs; color = inhibition % on MAPK8.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…