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STK11/STRADA/CAB39(LKB1)

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UniProt STK11:Q15831; STRADA:Q7RTN6; CAB39:Q9Y376 · PDB · AlphaFold · Substrate: LKB1tide · Clone: full length

Top inhibitors

#DrugInhibitionResidualKISSGini
1Pacritinib76.7%23.3%88.640.452
2Repotrectinib68.2%31.8%84.210.608
3Defactinib53.7%46.3%92.680.450
4Pralsetinib35.2%64.8%93.430.643
5Pexidartinib34.4%65.6%99.490.631
6Pazopanib21.2%78.8%97.490.672
7Entrectinib18.3%81.7%93.690.671
8Fostamatinib17.6%82.4%96.740.613
9Netarsudil16.4%83.6%93.220.676
10Quizartinib14.0%86.0%99.500.737
11Canertinib12.8%87.2%96.490.671
12Zanubrutinib11.9%88.1%98.240.788
13Capivasertib11.5%88.5%96.480.644
14Midostaurin10.7%89.3%78.640.500
15Capmatinib10.3%89.7%99.750.582
16Sunitinib9.4%90.6%91.730.524
17Gilteritinib9.1%90.9%88.970.506
18Umbralisib8.0%92.0%98.740.670
19Baricitinib7.9%92.1%97.990.616
20Deucravacitinib6.8%93.2%98.990.718

Paralog block

No paralog group registered for this kinase.

EMT expression

Not in the EMT expression panel.

Selectivity landscape vs inhibition on STK11/STRADA/CAB39

Each point is one of the 92 approved drugs; color = inhibition % on STK11/STRADA/CAB39.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

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