UniProt Q52WX2 · PDB · AlphaFold · Substrate: PKA sub · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Brigatinib | 60.4% | 39.6% | 82.96 | 0.513 |
| 2 | Capivasertib | 27.1% | 72.9% | 96.48 | 0.644 |
| 3 | Avapritinib | 18.0% | 82.0% | 97.73 | 0.644 |
| 4 | Defactinib | 16.3% | 83.7% | 92.68 | 0.450 |
| 5 | Pirtobrutinib | 13.2% | 86.8% | 99.49 | 0.656 |
| 6 | Pemigatinib | 12.5% | 87.5% | 98.23 | 0.718 |
| 7 | Pacritinib | 10.7% | 89.3% | 88.64 | 0.452 |
| 8 | Apatinib | 9.9% | 90.1% | 97.73 | 0.704 |
| 9 | Capmatinib | 9.9% | 90.1% | 99.75 | 0.582 |
| 10 | Sorafenib | 9.3% | 90.7% | 96.72 | 0.776 |
| 11 | Darovasertib | 9.1% | 90.9% | 96.99 | 0.719 |
| 12 | Pralsetinib | 8.8% | 91.2% | 93.43 | 0.643 |
| 13 | Idelalisib | 8.4% | 91.6% | 100.00 | 0.701 |
| 14 | Infigratinib | 8.3% | 91.7% | 98.24 | 0.710 |
| 15 | Crizotinib | 8.1% | 91.9% | 91.39 | 0.581 |
| 16 | Selpercatinib | 7.6% | 92.4% | 96.72 | 0.635 |
| 17 | Lazertinib | 7.5% | 92.5% | 97.47 | 0.674 |
| 18 | Mitapivat | 7.5% | 92.5% | 100.00 | 0.625 |
| 19 | Mobocertinib | 7.3% | 92.7% | 97.22 | 0.757 |
| 20 | Ponatinib | 6.9% | 93.1% | 78.23 | 0.534 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.32
- Epithelial log2(TPM+1): 1.93
- Fold change: -1.61
- Status: Downregulated
Selectivity landscape vs inhibition on SBK1
Each point is one of the 92 approved drugs; color = inhibition % on SBK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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