UniProt P43405 · PDB · AlphaFold · Substrate: pEY · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Midostaurin | 82.9% | 17.1% | 78.64 | 0.500 |
| 2 | Pacritinib | 73.9% | 26.1% | 88.64 | 0.452 |
| 3 | Gilteritinib | 72.7% | 27.3% | 88.97 | 0.506 |
| 4 | Bosutinib | 69.0% | 31.0% | 87.22 | 0.555 |
| 5 | Pralsetinib | 68.4% | 31.6% | 93.43 | 0.643 |
| 6 | Lazertinib | 66.4% | 33.6% | 97.47 | 0.674 |
| 7 | Crizotinib | 47.0% | 53.0% | 91.39 | 0.581 |
| 8 | Defactinib | 47.0% | 53.0% | 92.68 | 0.450 |
| 9 | Fostamatinib | 46.0% | 54.0% | 96.74 | 0.613 |
| 10 | Brigatinib | 42.9% | 57.1% | 82.96 | 0.513 |
| 11 | Dasatinib | 40.0% | 60.0% | 87.97 | 0.699 |
| 12 | Avapritinib | 33.2% | 66.8% | 97.73 | 0.644 |
| 13 | Selumetinib | 29.1% | 70.9% | 100.00 | 0.640 |
| 14 | Umbralisib | 23.4% | 76.6% | 98.74 | 0.670 |
| 15 | Paxalisib | 22.3% | 77.7% | 99.75 | 0.609 |
| 16 | Ceritinib | 21.2% | 78.8% | 95.44 | 0.618 |
| 17 | Leniolisib | 19.5% | 80.5% | 100.00 | 0.604 |
| 18 | Neratinib | 17.0% | 83.0% | 93.18 | 0.597 |
| 19 | Fedratinib | 12.4% | 87.6% | 96.21 | 0.576 |
| 20 | Entrectinib | 10.6% | 89.4% | 93.69 | 0.671 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.20
- Epithelial log2(TPM+1): 2.63
- Fold change: -2.43
- Status: Downregulated
Selectivity landscape vs inhibition on SYK
Each point is one of the 92 approved drugs; color = inhibition % on SYK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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