SRR11296800
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.260
- KRAS_SIGNALING_DN+0.070
- SPERMATOGENESIS+0.040
- PANCREAS_BETA_CELLS+0.030
- UV_RESPONSE_DN+0.000
- MITOTIC_SPINDLE-0.020
- BILE_ACID_METABOLISM-0.040
- FATTY_ACID_METABOLISM-0.070
- HEDGEHOG_SIGNALING-0.070
- PEROXISOME-0.070
Top 10 suppressed
- ANGIOGENESIS-0.520
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- MTORC1_SIGNALING-0.470
- INTERFERON_ALPHA_RESPONSE-0.450
- MYC_TARGETS_V1-0.420
- INTERFERON_GAMMA_RESPONSE-0.410
- GLYCOLYSIS-0.350
- UNFOLDED_PROTEIN_RESPONSE-0.340
- E2F_TARGETS-0.330
- G2M_CHECKPOINT-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | C3N-03420 | — | cohortA1 | 0.925 |
| 2 | BS_0Y66ZBWE | low-grade glioma | — | 0.918 |
| 3 | SRR8518450 | — | A | 0.912 |
| 4 | SRR1516050 | — | — | 0.912 |
| 5 | dab9a230-f4f6-4692-863a-5fdcf516be24 | — | — | 0.907 |
| 6 | SRR12696768 | — | — | 0.906 |
| 7 | SRR8613727 | — | D | 0.904 |
| 8 | AUR-AFE5-TTM9-A-1-1-R-A742-41 | — | D | 0.900 |
| 9 | SRR23303775 | — | — | 0.899 |
| 10 | SRR12696758 | — | — | 0.899 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.260 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.070 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.040 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.030 | Cobimetinib | — uncovered |