SRR8943008

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e150d30e-622c-5bd8-a716-1484f30efb1e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

BILE_ACID_METABOLISM+0.150
NOTCH_SIGNALING+0.040
PEROXISOME+0.040
TGF_BETA_SIGNALING+0.010
WNT_BETA_CATENIN_SIGNALING+0.010
MYC_TARGETS_V2-0.020
PROTEIN_SECRETION-0.050
KRAS_SIGNALING_DN-0.090
PANCREAS_BETA_CELLS-0.090
XENOBIOTIC_METABOLISM-0.090

Top 10 suppressed

E2F_TARGETS-0.570
G2M_CHECKPOINT-0.550
EPITHELIAL_MESENCHYMAL_TRANSITION-0.510
ANGIOGENESIS-0.490
CHOLESTEROL_HOMEOSTASIS-0.450
IL6_JAK_STAT3_SIGNALING-0.440
INTERFERON_ALPHA_RESPONSE-0.430
INTERFERON_GAMMA_RESPONSE-0.410
INFLAMMATORY_RESPONSE-0.360
MTORC1_SIGNALING-0.360

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	C3N-03420 lung-landscapes@6	—	cohortA1	0.929
2	R247 bladder-landscape@3	—	—	0.925
3	TCGA-CF-A5U8-01A-11R-A28M-07 bladder-landscape@3	—	—	0.911
4	TCGA-LT-A8JT-01A-11R-A36F-07 bladder-landscape@3	—	—	0.909
5	TCGA-CF-A27C-01A-11R-A16R-07 bladder-landscape@3	—	—	0.903
6	EPT0291 medullo-epn-umap@date-based	EPN	EPN Tumor	0.896
7	SRR8613727 breast-umap@18	—	D	0.894
8	SRR8942980 bladder-landscape@3	—	—	0.893
9	TCGA-FD-A43X-01A-11R-A23W-07 bladder-landscape@3	—	—	0.892
10	MBCProject_0004_T1_RNA breast-umap@18	—	C	0.890

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
BILE_ACID_METABOLISM	0.150	Inavolisib	— uncovered
NOTCH_SIGNALING	0.040	Inavolisib	— uncovered
PEROXISOME	0.040	Idelalisib	— uncovered
TGF_BETA_SIGNALING	0.010	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.010	Inavolisib	— uncovered