SRR12696770

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03b0c194-f2d4-50cd-b529-84080dba9ffd

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

E2F_TARGETS+0.200
G2M_CHECKPOINT+0.200
MITOTIC_SPINDLE+0.200
SPERMATOGENESIS+0.200
KRAS_SIGNALING_DN+0.100
PANCREAS_BETA_CELLS+0.100
APICAL_JUNCTION+0.000
BILE_ACID_METABOLISM+0.000
COAGULATION+0.000
DNA_REPAIR+0.000

Top 10 suppressed

ALLOGRAFT_REJECTION-0.500
IL6_JAK_STAT3_SIGNALING-0.500
INFLAMMATORY_RESPONSE-0.400
INTERFERON_ALPHA_RESPONSE-0.400
INTERFERON_GAMMA_RESPONSE-0.400
OXIDATIVE_PHOSPHORYLATION-0.400
PI3K_AKT_MTOR_SIGNALING-0.400
COMPLEMENT-0.300
IL2_STAT5_SIGNALING-0.300
MYC_TARGETS_V1-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#	Sample	Cancer type	Subtype	cos similarity
1	SRR13780248 lung-landscapes@6	—	cohortSC	0.874
2	BS_4E1G7E3G brain-umap@2	ATRT	—	0.865
3	BS_4W68NV3M brain-umap@2	medulloblastoma	—	0.862
4	266352 medullo-epn-umap@date-based	EPN	EPN Tumor	0.860
5	SRR23303774 bladder-landscape@3	—	—	0.859
6	BS_S1M423AB brain-umap@2	Embryonal tumors	—	0.854
7	SRR8518343 breast-umap@18	—	E	0.852
8	SRR22247242 lung-landscapes@6	—	cohortSC	0.851
9	BS_W311713R brain-umap@2	medulloblastoma	—	0.848
10	SRR6013518 lung-landscapes@6	—	cohortSQ1	0.847

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 6 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
E2F_TARGETS	0.200	Inavolisib	— uncovered
G2M_CHECKPOINT	0.200	Inavolisib	— uncovered
MITOTIC_SPINDLE	0.200	Inavolisib	— uncovered
SPERMATOGENESIS	0.200	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.100	Remibrutinib	— uncovered
PANCREAS_BETA_CELLS	0.100	Cobimetinib	— uncovered