TCGA-S5-AA26-01A-11R-A38B-07
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 16.52431012
- os_event
- false
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.350
- SPERMATOGENESIS+0.190
- BILE_ACID_METABOLISM+0.110
- ESTROGEN_RESPONSE_LATE+0.070
- HEDGEHOG_SIGNALING+0.030
- XENOBIOTIC_METABOLISM+0.010
- HYPOXIA+0.000
- COAGULATION-0.030
- G2M_CHECKPOINT-0.030
- P53_PATHWAY-0.040
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.530
- INTERFERON_GAMMA_RESPONSE-0.520
- PROTEIN_SECRETION-0.520
- MYC_TARGETS_V1-0.480
- INFLAMMATORY_RESPONSE-0.450
- ALLOGRAFT_REJECTION-0.440
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
- IL6_JAK_STAT3_SIGNALING-0.430
- UNFOLDED_PROTEIN_RESPONSE-0.400
- COMPLEMENT-0.390
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1379562 | GTEX | — | 0.899 |
| 2 | MNG189 | — | — | 0.898 |
| 3 | SRR1336379 | GTEX | — | 0.893 |
| 4 | TCGA-XF-A8HG-01A-11R-A36F-07 | — | — | 0.893 |
| 5 | SRR33346947 | — | — | 0.892 |
| 6 | TCGA-KQ-A41O-01A-12R-A352-07 | — | — | 0.889 |
| 7 | TCGA-E7-A7PW-01A-11R-A352-07 | — | — | 0.887 |
| 8 | MNG584 | — | — | 0.886 |
| 9 | ERR4976615 | — | D | 0.882 |
| 10 | SRR1406561 | GTEX | — | 0.882 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.350 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.190 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.110 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.070 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.030 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.010 | Inavolisib | — uncovered |