d220785b-6de0-4b89-a402-3d2cdcda4b2f
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.200
- PROTEIN_SECRETION+0.200
- INTERFERON_ALPHA_RESPONSE+0.100
- ANDROGEN_RESPONSE+0.000
- COAGULATION+0.000
- COMPLEMENT+0.000
- E2F_TARGETS+0.000
- G2M_CHECKPOINT+0.000
- HEME_METABOLISM+0.000
- INTERFERON_GAMMA_RESPONSE+0.000
Top 10 suppressed
- ADIPOGENESIS-0.300
- ANGIOGENESIS-0.300
- CHOLESTEROL_HOMEOSTASIS-0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
- MYC_TARGETS_V2-0.300
- MYOGENESIS-0.300
- OXIDATIVE_PHOSPHORYLATION-0.300
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.300
- APICAL_JUNCTION-0.200
- ESTROGEN_RESPONSE_LATE-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-3269 | Med | Medulloblastoma | 0.825 |
| 2 | TCGA-E2-A15I-01A-21R-A137-07 | — | B | 0.759 |
| 3 | SRR4195674 | — | — | 0.756 |
| 4 | SRR4195665 | — | — | 0.753 |
| 5 | MNG452 | — | — | 0.748 |
| 6 | SRR35579813 | — | B | 0.748 |
| 7 | TCGA-78-7143-01A-11R-2039-07 | — | cohortA1 | 0.738 |
| 8 | SRR8942972 | — | — | 0.729 |
| 9 | 0357aa51-9436-4923-9b1e-eb22bdf647df | — | — | 0.724 |
| 10 | SJEPD030097_D2.RNA-Seq | EPN | Spinal EPN | 0.723 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.100 | Inavolisib | — uncovered |