SRR12202498
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.220
- PANCREAS_BETA_CELLS+0.070
- WNT_BETA_CATENIN_SIGNALING-0.010
- MYC_TARGETS_V2-0.080
- MYOGENESIS-0.080
- APICAL_SURFACE-0.090
- GLYCOLYSIS-0.120
- BILE_ACID_METABOLISM-0.130
- SPERMATOGENESIS-0.130
- CHOLESTEROL_HOMEOSTASIS-0.140
Top 10 suppressed
- E2F_TARGETS-0.490
- TNFA_SIGNALING_VIA_NFKB-0.470
- ALLOGRAFT_REJECTION-0.460
- IL2_STAT5_SIGNALING-0.460
- INFLAMMATORY_RESPONSE-0.460
- OXIDATIVE_PHOSPHORYLATION-0.430
- ANDROGEN_RESPONSE-0.410
- APOPTOSIS-0.410
- IL6_JAK_STAT3_SIGNALING-0.410
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.390
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR650197 | — | — | 0.940 |
| 2 | SRR1516072 | — | — | 0.938 |
| 3 | SRR23303752 | — | — | 0.937 |
| 4 | aMVAC.P_005_TURBT_S223 | — | — | 0.934 |
| 5 | SRR1388504 | GTEX | — | 0.925 |
| 6 | SRR1797231 | — | cohortSC | 0.925 |
| 7 | SRR23303775 | — | — | 0.922 |
| 8 | SRR1334717 | GTEX | — | 0.918 |
| 9 | SRR1467813 | GTEX | — | 0.918 |
| 10 | SRR11296796 | — | — | 0.912 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 2 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.220 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.070 | Cobimetinib | — uncovered |