SRR1408769
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.324
- MYOGENESIS+0.256
- HEDGEHOG_SIGNALING+0.189
- SPERMATOGENESIS+0.178
- XENOBIOTIC_METABOLISM+0.147
- COAGULATION+0.141
- ESTROGEN_RESPONSE_LATE+0.137
- OXIDATIVE_PHOSPHORYLATION+0.134
- PANCREAS_BETA_CELLS+0.085
- BILE_ACID_METABOLISM+0.078
Top 10 suppressed
- MYC_TARGETS_V2-0.550
- UNFOLDED_PROTEIN_RESPONSE-0.523
- MYC_TARGETS_V1-0.507
- G2M_CHECKPOINT-0.493
- E2F_TARGETS-0.478
- CHOLESTEROL_HOMEOSTASIS-0.464
- MTORC1_SIGNALING-0.455
- PROTEIN_SECRETION-0.437
- DNA_REPAIR-0.410
- ANDROGEN_RESPONSE-0.381
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1337074 | GTEX | — | 0.951 |
| 2 | SRR1379450 | GTEX | — | 0.943 |
| 3 | SRR1381632 | GTEX | — | 0.938 |
| 4 | SRR1365987 | GTEX | — | 0.930 |
| 5 | SRR1456950 | GTEX | — | 0.930 |
| 6 | SRR1417505 | GTEX | — | 0.929 |
| 7 | SRR1472663 | GTEX | — | 0.926 |
| 8 | SRR1349013 | GTEX | — | 0.926 |
| 9 | SRR1332048 | GTEX | — | 0.923 |
| 10 | SRR1443824 | GTEX | — | 0.922 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.324 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.256 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.189 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.178 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.147 | Inavolisib | — uncovered |
| COAGULATION | 0.141 | Binimetinib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.137 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.134 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.085 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.078 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.039 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.038 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.034 | Inavolisib | — uncovered |