264656b8-d45c-4f5c-a431-366c566296fe
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.400
- OXIDATIVE_PHOSPHORYLATION+0.200
- PANCREAS_BETA_CELLS+0.200
- SPERMATOGENESIS+0.200
- BILE_ACID_METABOLISM+0.100
- KRAS_SIGNALING_DN+0.100
- DNA_REPAIR+0.000
- FATTY_ACID_METABOLISM+0.000
- HEDGEHOG_SIGNALING+0.000
- MYC_TARGETS_V1+0.000
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.600
- ALLOGRAFT_REJECTION-0.500
- IL6_JAK_STAT3_SIGNALING-0.500
- INFLAMMATORY_RESPONSE-0.500
- TGF_BETA_SIGNALING-0.500
- TNFA_SIGNALING_VIA_NFKB-0.500
- APICAL_JUNCTION-0.400
- APOPTOSIS-0.400
- COMPLEMENT-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E5-A4U1-01A-11R-A31N-07 | — | — | 0.943 |
| 2 | TCGA-KU-A66S-01A-21R-A30B-07 | — | — | 0.932 |
| 3 | SRR5088853 | — | — | 0.916 |
| 4 | TCGA-DK-AA75-01A-11R-A39I-07 | — | — | 0.902 |
| 5 | SRR4296068 | — | cohortA1 | 0.895 |
| 6 | TCGA-CF-A47T-01A-11R-A23W-07 | — | — | 0.893 |
| 7 | R249 | — | — | 0.888 |
| 8 | SRR1485892 | GTEX | — | 0.886 |
| 9 | MNG887 | — | — | 0.886 |
| 10 | TCGA-KQ-A41O-01A-12R-A352-07 | — | — | 0.880 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.200 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.200 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |