MNG598
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.434
- KRAS_SIGNALING_DN+0.405
- SPERMATOGENESIS+0.293
- COAGULATION-0.008
- MYOGENESIS-0.028
- APICAL_SURFACE-0.074
- ANGIOGENESIS-0.099
- ESTROGEN_RESPONSE_LATE-0.140
- ESTROGEN_RESPONSE_EARLY-0.141
- INFLAMMATORY_RESPONSE-0.145
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.603
- MYC_TARGETS_V1-0.578
- UNFOLDED_PROTEIN_RESPONSE-0.564
- PROTEIN_SECRETION-0.563
- TGF_BETA_SIGNALING-0.542
- DNA_REPAIR-0.535
- MYC_TARGETS_V2-0.534
- ADIPOGENESIS-0.509
- MTORC1_SIGNALING-0.502
- INTERFERON_ALPHA_RESPONSE-0.490
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG555 | — | — | 0.985 |
| 2 | msclc569389_S35.txt | — | cohortMD1 | 0.985 |
| 3 | MNG597 | — | — | 0.984 |
| 4 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.982 |
| 5 | MNG1131 | — | — | 0.981 |
| 6 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.979 |
| 7 | SRR12696761 | — | — | 0.975 |
| 8 | MNG1259 | — | — | 0.974 |
| 9 | SRR1366141 | GTEX | — | 0.973 |
| 10 | MNG90 | — | — | 0.973 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.434 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.405 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.293 | Inavolisib | — uncovered |