17abac39-baa9-4ea1-83bd-543ba319e246
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.300
- NOTCH_SIGNALING+0.300
- UV_RESPONSE_DN+0.300
- ANDROGEN_RESPONSE+0.200
- PEROXISOME+0.200
- TGF_BETA_SIGNALING+0.200
- BILE_ACID_METABOLISM+0.100
- COAGULATION+0.100
- FATTY_ACID_METABOLISM+0.100
- KRAS_SIGNALING_UP+0.100
Top 10 suppressed
- CHOLESTEROL_HOMEOSTASIS-0.400
- MTORC1_SIGNALING-0.400
- MYC_TARGETS_V2-0.400
- ESTROGEN_RESPONSE_LATE-0.300
- P53_PATHWAY-0.300
- PI3K_AKT_MTOR_SIGNALING-0.300
- SPERMATOGENESIS-0.300
- UNFOLDED_PROTEIN_RESPONSE-0.300
- COMPLEMENT-0.200
- GLYCOLYSIS-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SAMN03290900 | — | — | 0.680 |
| 2 | ULC0424T_S49 | — | cohortA1 | 0.675 |
| 3 | s0094268 | — | — | 0.662 |
| 4 | TCGA-A7-A26E-01A-11R-A169-07 | — | B | 0.647 |
| 5 | TCGA-A7-A0DB-01A-11R-A277-07 | — | D | 0.635 |
| 6 | SJEPD030399_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.630 |
| 7 | SRR6013544 | — | cohortA1 | 0.629 |
| 8 | TCGA-D8-A1XO-01A-11R-A14M-07 | — | B | 0.626 |
| 9 | TCGA-44-2665-01A-01R-A278-07 | — | cohortMD2 | 0.625 |
| 10 | MBCProject_0719_T3_RNA | — | A | 0.621 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.300 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.300 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.300 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.200 | Inavolisib | — uncovered |
| PEROXISOME | 0.200 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.200 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| COAGULATION | 0.100 | Binimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.100 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.100 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.100 | Remibrutinib | — uncovered |