s0094268
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.300
- ANGIOGENESIS+0.200
- HEDGEHOG_SIGNALING+0.200
- BILE_ACID_METABOLISM+0.100
- FATTY_ACID_METABOLISM+0.100
- KRAS_SIGNALING_UP+0.100
- PROTEIN_SECRETION+0.100
- ADIPOGENESIS+0.000
- ALLOGRAFT_REJECTION+0.000
- ANDROGEN_RESPONSE+0.000
Top 10 suppressed
- MYC_TARGETS_V2-0.600
- CHOLESTEROL_HOMEOSTASIS-0.400
- INTERFERON_ALPHA_RESPONSE-0.400
- MTORC1_SIGNALING-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- E2F_TARGETS-0.300
- INTERFERON_GAMMA_RESPONSE-0.300
- APOPTOSIS-0.200
- DNA_REPAIR-0.200
- G2M_CHECKPOINT-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR4195677 | — | — | 0.825 |
| 2 | MBCProject_3947_T1_RNA | — | A | 0.816 |
| 3 | SRR8518163 | — | A | 0.814 |
| 4 | ULC0424T_S49 | — | cohortA1 | 0.808 |
| 5 | TCGA-97-8174-01A-11R-2287-07 | — | cohortA2 | 0.793 |
| 6 | TCGA-WA-A7H4-01A-21R-A34R-07 | — | — | 0.792 |
| 7 | SRR8613705 | — | A | 0.784 |
| 8 | TCGA-A7-A0DB-01A-11R-A277-07 | — | D | 0.784 |
| 9 | SRR10900003 | — | — | 0.778 |
| 10 | 8ee55a63-4e87-4c00-8012-4c87efdcb7ed | — | — | 0.777 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.300 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.200 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.200 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.100 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.100 | Remibrutinib | — uncovered |