MNG717
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202409 | — | — | 0.844 |
| 2 | MBCProject_0988_T1_RNA | — | B | 0.802 |
| 3 | 44f9e45d-d779-4865-8f10-d085d5d25447 | — | — | 0.799 |
| 4 | 40b92a76-f324-4cdd-8209-517d021acd47 | — | — | 0.784 |
| 5 | c0054cf0-8f4b-47b6-a8fc-63a1fd36bcc7 | — | — | 0.777 |
| 6 | SAMN03290915 | — | — | 0.776 |
| 7 | 06c948c5-b714-40b8-b4ce-814effef62c7 | — | — | 0.772 |
| 8 | SJEPD001521_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.769 |
| 9 | SJEPD001505_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.753 |
| 10 | 9a4f9e4a-dc97-4f8d-9075-537b62fb98d3 | — | — | 0.751 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 30 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_LATE | 0.367 | Idelalisib | — uncovered |
| MYOGENESIS | 0.358 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.342 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.341 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.320 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.317 | Inavolisib | — uncovered |
| COAGULATION | 0.277 | Binimetinib | — uncovered |
| ANGIOGENESIS | 0.274 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.231 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.213 | Inavolisib | — uncovered |
| HYPOXIA | 0.213 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.206 | Idelalisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.204 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.195 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.179 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.164 | Inavolisib | — uncovered |
| PEROXISOME | 0.163 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.150 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.139 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.136 | Inavolisib | — uncovered |