7b837bdd-5a59-47f6-a1aa-259142234bd5
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 80
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- IL6_JAK_STAT3_SIGNALING+0.230
- HEDGEHOG_SIGNALING+0.210
- ALLOGRAFT_REJECTION+0.200
- INFLAMMATORY_RESPONSE+0.200
- INTERFERON_ALPHA_RESPONSE+0.180
- INTERFERON_GAMMA_RESPONSE+0.170
- WNT_BETA_CATENIN_SIGNALING+0.110
- KRAS_SIGNALING_UP+0.090
- PANCREAS_BETA_CELLS+0.070
- KRAS_SIGNALING_DN+0.030
Top 10 suppressed
- CHOLESTEROL_HOMEOSTASIS-0.520
- OXIDATIVE_PHOSPHORYLATION-0.430
- MTORC1_SIGNALING-0.420
- GLYCOLYSIS-0.400
- MYC_TARGETS_V2-0.400
- PROTEIN_SECRETION-0.380
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.360
- MYC_TARGETS_V1-0.340
- ADIPOGENESIS-0.330
- APICAL_SURFACE-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG882 | — | — | 0.864 |
| 2 | TCGA-93-A4JO-01A-21R-A24X-07 | — | cohortA1 | 0.860 |
| 3 | SRR12202433 | — | — | 0.858 |
| 4 | TCGA-91-A4BC-01A-11R-A24H-07 | — | cohortA3 | 0.855 |
| 5 | X65f5effa.07f7.4ed3.9e0a.3a0d9d451474 | — | cohortA1 | 0.854 |
| 6 | MNG1098 | — | — | 0.846 |
| 7 | ERR2208971 | — | — | 0.844 |
| 8 | s0122234 | — | — | 0.844 |
| 9 | 6b907244-c173-4e29-a163-24258a430477 | — | — | 0.844 |
| 10 | MNG450 | — | — | 0.840 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| IL6_JAK_STAT3_SIGNALING | 0.230 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.210 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.200 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.200 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.180 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.170 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.110 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.090 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.070 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.030 | Remibrutinib | — uncovered |