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ERR2208971

c00a8fd5-0605-5261-8c42-3dfbb225286a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.300
  • INTERFERON_ALPHA_RESPONSE+0.300
  • INTERFERON_GAMMA_RESPONSE+0.300
  • IL6_JAK_STAT3_SIGNALING+0.100
  • TNFA_SIGNALING_VIA_NFKB+0.100
  • UV_RESPONSE_DN+0.100
  • WNT_BETA_CATENIN_SIGNALING+0.100
  • APICAL_JUNCTION+0.000
  • HEDGEHOG_SIGNALING+0.000
  • INFLAMMATORY_RESPONSE+0.000

Top 10 suppressed

  • MYC_TARGETS_V1-0.700
  • OXIDATIVE_PHOSPHORYLATION-0.600
  • E2F_TARGETS-0.500
  • MTORC1_SIGNALING-0.500
  • PROTEIN_SECRETION-0.500
  • ADIPOGENESIS-0.400
  • ANDROGEN_RESPONSE-0.400
  • MYC_TARGETS_V2-0.400
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
  • ANGIOGENESIS-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1X65f5effa.07f7.4ed3.9e0a.3a0d9d451474
lung-landscapes@6
cohortA10.902
2s0122234
melanoma-umap@29
0.880
3ERR2208899
melanoma-umap@29
0.868
4TCGA-MN-A4N5-01A-11R-A24X-07
lung-landscapes@6
cohortA10.864
5AUR-AFSP-TTP1-A-8-0-R-A741-41
breast-umap@18
D0.855
6SRR5088847
melanoma-umap@29
0.853
720040121.LumB
breast-umap@18
D0.849
87b837bdd-5a59-47f6-a1aa-259142234bd5
colon-landscapes@1
0.844
9TCGA-AC-A3OD-01B-06R-A22O-07
breast-umap@18
D0.844
10bae6fdb5-9df3-433c-9a4c-e5c159a62bc6
colon-landscapes@1
0.839

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 7 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.300Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.300Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.300Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.100Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.100Inavolisib— uncovered
UV_RESPONSE_DN0.100Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.100Inavolisib— uncovered