R15
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 43
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.340
- NOTCH_SIGNALING+0.150
- HEDGEHOG_SIGNALING+0.140
- MYOGENESIS+0.140
- UV_RESPONSE_DN+0.140
- DNA_REPAIR+0.120
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.120
- MITOTIC_SPINDLE+0.050
- APICAL_JUNCTION+0.040
- KRAS_SIGNALING_DN+0.020
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.400
- MTORC1_SIGNALING-0.390
- PROTEIN_SECRETION-0.360
- HYPOXIA-0.340
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.330
- P53_PATHWAY-0.320
- MYC_TARGETS_V1-0.290
- UV_RESPONSE_UP-0.290
- ANDROGEN_RESPONSE-0.280
- ANGIOGENESIS-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_0719_T1_RNA | — | A | 0.853 |
| 2 | MBCProject_0589_T1_RNA | — | A | 0.845 |
| 3 | SRR4195673 | — | — | 0.833 |
| 4 | SRR4195662 | — | — | 0.832 |
| 5 | TCGA-90-A4ED-01A-31R-A24Z-07 | — | cohortMD1 | 0.831 |
| 6 | GSM5359422 | — | — | 0.820 |
| 7 | BS_GR46VD0Q | low-grade glioma | — | 0.809 |
| 8 | SRR4296062 | — | cohortA1 | 0.807 |
| 9 | MBCProject_0589_T1A_RNA | — | A | 0.803 |
| 10 | AUR-AFE5-TTM9-A-1-1-R-A742-41 | — | D | 0.802 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.340 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.150 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.140 | Inavolisib | — uncovered |
| MYOGENESIS | 0.140 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.140 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.120 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.120 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.050 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.040 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |