SRR8518272
— · E
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- E
- subtype
- E
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.310
- SPERMATOGENESIS+0.270
- PROTEIN_SECRETION+0.250
- BILE_ACID_METABOLISM+0.170
- KRAS_SIGNALING_DN+0.150
- ADIPOGENESIS+0.140
- PEROXISOME+0.120
- FATTY_ACID_METABOLISM+0.090
- ANDROGEN_RESPONSE+0.050
- HEME_METABOLISM+0.020
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.510
- ALLOGRAFT_REJECTION-0.460
- COMPLEMENT-0.410
- INFLAMMATORY_RESPONSE-0.410
- G2M_CHECKPOINT-0.400
- ANGIOGENESIS-0.390
- IL6_JAK_STAT3_SIGNALING-0.360
- INTERFERON_GAMMA_RESPONSE-0.350
- COAGULATION-0.340
- NOTCH_SIGNALING-0.340
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_9NJHQE9F | Med | Medulloblastoma | 0.876 |
| 2 | SRR655134 | GTEX | — | 0.875 |
| 3 | SAMN03290937 | — | — | 0.873 |
| 4 | SRR35579848 | — | B | 0.869 |
| 5 | MBCProject_0343_T1_RNA | — | B | 0.855 |
| 6 | SRR10900001 | — | — | 0.855 |
| 7 | SRR1322555 | GTEX | — | 0.850 |
| 8 | SRR2770872 | — | — | 0.847 |
| 9 | TCGA-B6-A0X4-01A-11R-A109-07 | — | B | 0.847 |
| 10 | SRR1464327 | GTEX | — | 0.846 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.310 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.270 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.250 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.170 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.150 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.140 | Inavolisib | — uncovered |
| PEROXISOME | 0.120 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.090 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.050 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.020 | Temsirolimus | — uncovered |
| MYOGENESIS | 0.020 | Inavolisib | — uncovered |