SRR1322555
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.368
- KRAS_SIGNALING_DN+0.262
- SPERMATOGENESIS+0.218
- HEDGEHOG_SIGNALING+0.216
- MYOGENESIS+0.134
- ESTROGEN_RESPONSE_EARLY+0.037
- FATTY_ACID_METABOLISM+0.032
- PEROXISOME-0.001
- PROTEIN_SECRETION-0.028
- UV_RESPONSE_DN-0.028
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.547
- ALLOGRAFT_REJECTION-0.518
- IL6_JAK_STAT3_SIGNALING-0.506
- INTERFERON_GAMMA_RESPONSE-0.497
- INFLAMMATORY_RESPONSE-0.466
- ANGIOGENESIS-0.464
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.386
- E2F_TARGETS-0.381
- KRAS_SIGNALING_UP-0.364
- G2M_CHECKPOINT-0.355
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1474065 | GTEX | — | 0.975 |
| 2 | SRR1465356 | GTEX | — | 0.971 |
| 3 | SRR1339218 | GTEX | — | 0.962 |
| 4 | SRR1390601 | GTEX | — | 0.955 |
| 5 | SRR1477634 | GTEX | — | 0.955 |
| 6 | SRR600560 | GTEX | — | 0.955 |
| 7 | SRR1335651 | GTEX | — | 0.954 |
| 8 | SRR1353157 | GTEX | — | 0.952 |
| 9 | SRR1359388 | GTEX | — | 0.951 |
| 10 | SRR1370619 | GTEX | — | 0.951 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.368 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.262 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.218 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.216 | Inavolisib | — uncovered |
| MYOGENESIS | 0.134 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.037 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.032 | Inavolisib | — uncovered |