SRR663681
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.243
- MYC_TARGETS_V2+0.192
- OXIDATIVE_PHOSPHORYLATION+0.160
- UNFOLDED_PROTEIN_RESPONSE+0.105
- WNT_BETA_CATENIN_SIGNALING+0.044
- PEROXISOME+0.022
- MITOTIC_SPINDLE+0.019
- MYC_TARGETS_V1+0.000
- KRAS_SIGNALING_DN-0.007
- CHOLESTEROL_HOMEOSTASIS-0.010
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.562
- INTERFERON_GAMMA_RESPONSE-0.513
- INFLAMMATORY_RESPONSE-0.508
- IL6_JAK_STAT3_SIGNALING-0.497
- ANGIOGENESIS-0.480
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.467
- TNFA_SIGNALING_VIA_NFKB-0.451
- KRAS_SIGNALING_UP-0.443
- ALLOGRAFT_REJECTION-0.437
- COAGULATION-0.429
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1357413 | GTEX | — | 0.974 |
| 2 | SRR1471417 | GTEX | — | 0.969 |
| 3 | SRR1477385 | GTEX | — | 0.969 |
| 4 | SRR659412 | GTEX | — | 0.969 |
| 5 | SRR1359367 | GTEX | — | 0.969 |
| 6 | SRR1360038 | GTEX | — | 0.967 |
| 7 | SRR607311 | GTEX | — | 0.964 |
| 8 | SRR1499442 | GTEX | — | 0.964 |
| 9 | SRR1069188 | GTEX | — | 0.964 |
| 10 | SRR1464305 | GTEX | — | 0.963 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.243 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.192 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.160 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.105 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.044 | Inavolisib | — uncovered |
| PEROXISOME | 0.022 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.019 | Inavolisib | — uncovered |