SRR1069188
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.192
- OXIDATIVE_PHOSPHORYLATION+0.095
- KRAS_SIGNALING_DN+0.054
- UNFOLDED_PROTEIN_RESPONSE+0.018
- PI3K_AKT_MTOR_SIGNALING+0.007
- MYC_TARGETS_V1-0.025
- MITOTIC_SPINDLE-0.042
- MYC_TARGETS_V2-0.043
- PEROXISOME-0.049
- HEME_METABOLISM-0.052
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.489
- TNFA_SIGNALING_VIA_NFKB-0.481
- INTERFERON_ALPHA_RESPONSE-0.475
- ANGIOGENESIS-0.466
- INFLAMMATORY_RESPONSE-0.452
- INTERFERON_GAMMA_RESPONSE-0.423
- APOPTOSIS-0.421
- KRAS_SIGNALING_UP-0.419
- TGF_BETA_SIGNALING-0.410
- COAGULATION-0.398
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1385036 | GTEX | — | 0.979 |
| 2 | SRR820468 | GTEX | — | 0.977 |
| 3 | SRR1456531 | GTEX | — | 0.976 |
| 4 | SRR1360038 | GTEX | — | 0.974 |
| 5 | SRR807657 | GTEX | — | 0.974 |
| 6 | SRR1357413 | GTEX | — | 0.974 |
| 7 | SRR1477385 | GTEX | — | 0.973 |
| 8 | SRR659412 | GTEX | — | 0.972 |
| 9 | SRR1471417 | GTEX | — | 0.971 |
| 10 | SRR1348770 | GTEX | — | 0.970 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.192 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.095 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.054 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.018 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.007 | Inavolisib | — uncovered |