SRR8518258
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.240
- BILE_ACID_METABOLISM+0.090
- NOTCH_SIGNALING+0.090
- TGF_BETA_SIGNALING+0.080
- WNT_BETA_CATENIN_SIGNALING+0.070
- MITOTIC_SPINDLE+0.060
- ANDROGEN_RESPONSE+0.050
- HEME_METABOLISM+0.020
- PI3K_AKT_MTOR_SIGNALING+0.020
- HEDGEHOG_SIGNALING-0.020
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.480
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- ANGIOGENESIS-0.430
- MTORC1_SIGNALING-0.370
- IL6_JAK_STAT3_SIGNALING-0.350
- INTERFERON_GAMMA_RESPONSE-0.350
- APICAL_JUNCTION-0.330
- UNFOLDED_PROTEIN_RESPONSE-0.320
- COAGULATION-0.310
- INTERFERON_ALPHA_RESPONSE-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-0189 | Med | Medulloblastoma | 0.875 |
| 2 | MNG45 | — | — | 0.874 |
| 3 | SRR12475149 | — | — | 0.870 |
| 4 | TCGA-E7-A6MF-01A-12R-A32O-07 | — | — | 0.865 |
| 5 | TCGA-GU-A42R-01A-11R-A23N-07 | — | — | 0.860 |
| 6 | MDT-AP-3246 | Med | Medulloblastoma | 0.860 |
| 7 | SRR8942980 | — | — | 0.859 |
| 8 | SRR8518450 | — | A | 0.858 |
| 9 | SJEPD030911_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.857 |
| 10 | SRR650132 | — | — | 0.856 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.240 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.090 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.090 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.080 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.070 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.060 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.050 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.020 | Temsirolimus | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.020 | Inavolisib | — uncovered |