9cde93c5-569a-482a-901b-2bbc21aadfa2
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- FATTY_ACID_METABOLISM+0.100
- OXIDATIVE_PHOSPHORYLATION+0.100
- ALLOGRAFT_REJECTION+0.000
- BILE_ACID_METABOLISM+0.000
- INTERFERON_ALPHA_RESPONSE+0.000
- INTERFERON_GAMMA_RESPONSE+0.000
- KRAS_SIGNALING_DN+0.000
- PANCREAS_BETA_CELLS+0.000
- ADIPOGENESIS-0.100
- IL6_JAK_STAT3_SIGNALING-0.100
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- MTORC1_SIGNALING-0.500
- UNFOLDED_PROTEIN_RESPONSE-0.500
- DNA_REPAIR-0.400
- GLYCOLYSIS-0.400
- HYPOXIA-0.400
- PI3K_AKT_MTOR_SIGNALING-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- TGF_BETA_SIGNALING-0.400
- ANGIOGENESIS-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR25617833 | — | B | 0.863 |
| 2 | SRR33346946 | — | — | 0.858 |
| 3 | SAMN03290914 | — | — | 0.853 |
| 4 | SRR8943010 | — | — | 0.853 |
| 5 | SRR23303775 | — | — | 0.842 |
| 6 | SRR11296802 | — | — | 0.841 |
| 7 | TCGA-MP-A4T6-01A-32R-A262-07 | — | cohortA1 | 0.835 |
| 8 | SRR13311179 | — | — | 0.834 |
| 9 | SRR12202414 | — | — | 0.833 |
| 10 | SRR8942981 | — | — | 0.833 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 2 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.100 | Remibrutinib | — uncovered |