SRR627455
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.338
- UV_RESPONSE_DN+0.310
- KRAS_SIGNALING_DN+0.250
- PANCREAS_BETA_CELLS+0.161
- MITOTIC_SPINDLE+0.111
- APICAL_SURFACE+0.036
- KRAS_SIGNALING_UP+0.022
- INFLAMMATORY_RESPONSE-0.024
- HEDGEHOG_SIGNALING-0.030
- ANDROGEN_RESPONSE-0.070
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.573
- MYC_TARGETS_V1-0.560
- OXIDATIVE_PHOSPHORYLATION-0.540
- DNA_REPAIR-0.528
- MYC_TARGETS_V2-0.513
- ADIPOGENESIS-0.489
- P53_PATHWAY-0.481
- WNT_BETA_CATENIN_SIGNALING-0.460
- NOTCH_SIGNALING-0.452
- INTERFERON_ALPHA_RESPONSE-0.451
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR627462 | GTEX | — | 0.957 |
| 2 | SRR627429 | GTEX | — | 0.949 |
| 3 | SRR627449 | GTEX | — | 0.941 |
| 4 | b8135e73-31c3-49af-b4da-a7ed5f28d68a | — | — | 0.938 |
| 5 | d1447a31-64bb-4e70-ae50-eeff7a605f38 | — | — | 0.934 |
| 6 | 62454053-936d-4f19-8522-6219c47bdd1c | — | — | 0.928 |
| 7 | SRR627451 | GTEX | — | 0.928 |
| 8 | e356598b-7611-492a-98ed-ef2ec1b77b7a | — | — | 0.918 |
| 9 | 69550f7f-5251-4657-863b-bd35d69c82c4 | — | — | 0.911 |
| 10 | ed8896f8-24ef-43a4-ace6-ed9353bd11c2 | — | — | 0.909 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.338 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.310 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.250 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.161 | Cobimetinib | — uncovered |
| MITOTIC_SPINDLE | 0.111 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.036 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_UP | 0.022 | Inavolisib | — uncovered |