SRR25617918
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.280
- SPERMATOGENESIS+0.170
- KRAS_SIGNALING_DN+0.110
- PEROXISOME+0.060
- MYOGENESIS+0.040
- BILE_ACID_METABOLISM+0.030
- MYC_TARGETS_V2-0.050
- ESTROGEN_RESPONSE_LATE-0.060
- COAGULATION-0.080
- ESTROGEN_RESPONSE_EARLY-0.090
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.570
- INTERFERON_GAMMA_RESPONSE-0.560
- TNFA_SIGNALING_VIA_NFKB-0.450
- IL6_JAK_STAT3_SIGNALING-0.440
- PROTEIN_SECRETION-0.440
- INFLAMMATORY_RESPONSE-0.430
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.420
- ALLOGRAFT_REJECTION-0.410
- ANDROGEN_RESPONSE-0.410
- APOPTOSIS-0.390
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | aMVAC.P_005_TURBT_S223 | — | — | 0.942 |
| 2 | TCGA-KQ-A41O-01A-12R-A352-07 | — | — | 0.926 |
| 3 | TCGA-E7-A7PW-01A-11R-A352-07 | — | — | 0.920 |
| 4 | TCGA-E5-A4U1-01A-11R-A31N-07 | — | — | 0.916 |
| 5 | SRR1467813 | GTEX | — | 0.916 |
| 6 | SRR8943038 | — | — | 0.916 |
| 7 | SRR33346947 | — | — | 0.912 |
| 8 | SRR1379562 | GTEX | — | 0.909 |
| 9 | SRR1436444 | GTEX | — | 0.909 |
| 10 | SRR1516072 | — | — | 0.909 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.280 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.170 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.110 | Remibrutinib | — uncovered |
| PEROXISOME | 0.060 | Idelalisib | — uncovered |
| MYOGENESIS | 0.040 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.030 | Inavolisib | — uncovered |