SRR33346954
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.350
- WNT_BETA_CATENIN_SIGNALING+0.350
- TGF_BETA_SIGNALING+0.270
- APICAL_SURFACE+0.220
- MITOTIC_SPINDLE+0.170
- PROTEIN_SECRETION+0.160
- HEDGEHOG_SIGNALING+0.150
- P53_PATHWAY+0.070
- DNA_REPAIR+0.020
- APICAL_JUNCTION+0.010
Top 10 suppressed
- MTORC1_SIGNALING-0.350
- KRAS_SIGNALING_DN-0.330
- PANCREAS_BETA_CELLS-0.310
- COAGULATION-0.300
- E2F_TARGETS-0.290
- IL6_JAK_STAT3_SIGNALING-0.290
- INFLAMMATORY_RESPONSE-0.290
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.290
- GLYCOLYSIS-0.280
- SPERMATOGENESIS-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202454 | — | — | 0.815 |
| 2 | SRR650188 | — | — | 0.814 |
| 3 | SRR1516088 | — | — | 0.799 |
| 4 | MDT-AP-3271 | Med | Medulloblastoma | 0.788 |
| 5 | TCGA-A8-A09V-01A-11R-A034-07 | — | B | 0.769 |
| 6 | SRR1516046 | — | — | 0.764 |
| 7 | MDT-AP-3246 | Med | Medulloblastoma | 0.763 |
| 8 | SRR25617865 | — | A | 0.759 |
| 9 | SRR1516060 | — | — | 0.759 |
| 10 | TCGA-D8-A145-01A-11R-A115-07 | — | A | 0.757 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.350 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.350 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.270 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.220 | Temsirolimus | — uncovered |
| MITOTIC_SPINDLE | 0.170 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.160 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.150 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.070 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.020 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.010 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.010 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.010 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_UP | 0.010 | Inavolisib | — uncovered |