SRR12202454
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TGF_BETA_SIGNALING+0.380
- WNT_BETA_CATENIN_SIGNALING+0.320
- NOTCH_SIGNALING+0.290
- PROTEIN_SECRETION+0.180
- DNA_REPAIR+0.170
- OXIDATIVE_PHOSPHORYLATION+0.140
- HEME_METABOLISM+0.130
- P53_PATHWAY+0.090
- UV_RESPONSE_DN+0.090
- ESTROGEN_RESPONSE_EARLY-0.010
Top 10 suppressed
- E2F_TARGETS-0.560
- G2M_CHECKPOINT-0.520
- ALLOGRAFT_REJECTION-0.460
- IL6_JAK_STAT3_SIGNALING-0.420
- TNFA_SIGNALING_VIA_NFKB-0.410
- INFLAMMATORY_RESPONSE-0.370
- INTERFERON_GAMMA_RESPONSE-0.350
- MTORC1_SIGNALING-0.330
- SPERMATOGENESIS-0.330
- COMPLEMENT-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1516088 | — | — | 0.899 |
| 2 | TCGA-55-8087-01A-11R-2241-07 | — | cohortA1 | 0.838 |
| 3 | R229 | — | — | 0.832 |
| 4 | DRR168599 | — | — | 0.832 |
| 5 | TCGA-78-7167-01A-11R-2066-07 | — | cohortA2 | 0.831 |
| 6 | SRR8943023 | — | — | 0.829 |
| 7 | SRR1516046 | — | — | 0.829 |
| 8 | SRR1516060 | — | — | 0.827 |
| 9 | SRR8942980 | — | — | 0.826 |
| 10 | X2ea5b654.8b53.4e39.8f1a.129a46474ae2 | — | cohortA1 | 0.825 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.380 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.320 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.290 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.180 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.170 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.140 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.130 | Temsirolimus | — uncovered |
| P53_PATHWAY | 0.090 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.090 | Inavolisib | — uncovered |