SRR659331
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.348
- MITOTIC_SPINDLE+0.139
- MYC_TARGETS_V1+0.114
- PI3K_AKT_MTOR_SIGNALING+0.106
- UNFOLDED_PROTEIN_RESPONSE+0.101
- HEME_METABOLISM+0.100
- ANDROGEN_RESPONSE+0.089
- G2M_CHECKPOINT+0.075
- DNA_REPAIR+0.072
- MYC_TARGETS_V2+0.063
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.540
- ANGIOGENESIS-0.479
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.471
- TNFA_SIGNALING_VIA_NFKB-0.465
- INTERFERON_GAMMA_RESPONSE-0.459
- COAGULATION-0.431
- APOPTOSIS-0.421
- INFLAMMATORY_RESPONSE-0.421
- KRAS_SIGNALING_UP-0.366
- IL6_JAK_STAT3_SIGNALING-0.364
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR664819 | GTEX | — | 0.978 |
| 2 | SRR662871 | GTEX | — | 0.976 |
| 3 | SRR657325 | GTEX | — | 0.968 |
| 4 | SRR819999 | GTEX | — | 0.967 |
| 5 | SRR655864 | GTEX | — | 0.966 |
| 6 | SRR660812 | GTEX | — | 0.965 |
| 7 | SRR662570 | GTEX | — | 0.964 |
| 8 | SRR661290 | GTEX | — | 0.963 |
| 9 | SRR657997 | GTEX | — | 0.960 |
| 10 | SRR1080927 | GTEX | — | 0.958 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.348 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.139 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.114 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.106 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.101 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| ANDROGEN_RESPONSE | 0.089 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.075 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.072 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.063 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.037 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.020 | Inavolisib | — uncovered |
| PEROXISOME | 0.019 | Idelalisib | — uncovered |