SRR664819
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.375
- MYC_TARGETS_V1+0.151
- HEME_METABOLISM+0.120
- PI3K_AKT_MTOR_SIGNALING+0.109
- E2F_TARGETS+0.097
- ANDROGEN_RESPONSE+0.075
- SPERMATOGENESIS+0.069
- DNA_REPAIR+0.053
- MITOTIC_SPINDLE+0.052
- UNFOLDED_PROTEIN_RESPONSE+0.052
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.555
- ANGIOGENESIS-0.547
- TNFA_SIGNALING_VIA_NFKB-0.534
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.524
- INFLAMMATORY_RESPONSE-0.515
- INTERFERON_GAMMA_RESPONSE-0.506
- IL6_JAK_STAT3_SIGNALING-0.480
- COAGULATION-0.476
- CHOLESTEROL_HOMEOSTASIS-0.459
- APOPTOSIS-0.457
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657325 | GTEX | — | 0.978 |
| 2 | SRR659331 | GTEX | — | 0.978 |
| 3 | SRR662871 | GTEX | — | 0.975 |
| 4 | SRR819999 | GTEX | — | 0.971 |
| 5 | SRR655864 | GTEX | — | 0.967 |
| 6 | SRR661290 | GTEX | — | 0.965 |
| 7 | SRR662570 | GTEX | — | 0.964 |
| 8 | SRR657997 | GTEX | — | 0.963 |
| 9 | SRR660812 | GTEX | — | 0.960 |
| 10 | SRR656179 | GTEX | — | 0.959 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.375 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.151 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.120 | Temsirolimus | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.109 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.097 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.075 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.069 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.053 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.052 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.052 | Idelalisib | — uncovered |
| PEROXISOME | 0.039 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.031 | Inavolisib | — uncovered |