SRR660812
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.431
- UNFOLDED_PROTEIN_RESPONSE+0.213
- MYC_TARGETS_V1+0.205
- OXIDATIVE_PHOSPHORYLATION+0.202
- DNA_REPAIR+0.143
- MITOTIC_SPINDLE+0.128
- PI3K_AKT_MTOR_SIGNALING+0.118
- HEME_METABOLISM+0.115
- ANDROGEN_RESPONSE+0.103
- E2F_TARGETS+0.040
Top 10 suppressed
- ANGIOGENESIS-0.569
- INTERFERON_ALPHA_RESPONSE-0.532
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.509
- COAGULATION-0.505
- INTERFERON_GAMMA_RESPONSE-0.485
- TNFA_SIGNALING_VIA_NFKB-0.477
- INFLAMMATORY_RESPONSE-0.475
- ALLOGRAFT_REJECTION-0.472
- IL6_JAK_STAT3_SIGNALING-0.456
- APOPTOSIS-0.392
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR819999 | GTEX | — | 0.984 |
| 2 | SRR656179 | GTEX | — | 0.983 |
| 3 | SRR2167642 | GTEX | — | 0.980 |
| 4 | SRR662570 | GTEX | — | 0.973 |
| 5 | SRR662871 | GTEX | — | 0.969 |
| 6 | SRR659331 | GTEX | — | 0.965 |
| 7 | SRR1477773 | GTEX | — | 0.962 |
| 8 | SRR663453 | GTEX | — | 0.961 |
| 9 | SRR664819 | GTEX | — | 0.960 |
| 10 | SRR818188 | GTEX | — | 0.958 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.431 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.213 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.205 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.202 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.143 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.128 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.118 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.115 | Temsirolimus | — uncovered |
| ANDROGEN_RESPONSE | 0.103 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.040 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.038 | Inavolisib | — uncovered |
| PEROXISOME | 0.038 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.021 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.016 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.015 | Idelalisib | — uncovered |