MNG899
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.309
- HEDGEHOG_SIGNALING+0.260
- SPERMATOGENESIS+0.251
- E2F_TARGETS+0.247
- KRAS_SIGNALING_DN+0.152
- MITOTIC_SPINDLE+0.101
- PANCREAS_BETA_CELLS+0.065
- XENOBIOTIC_METABOLISM+0.043
- BILE_ACID_METABOLISM+0.021
- ESTROGEN_RESPONSE_EARLY-0.029
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.515
- TNFA_SIGNALING_VIA_NFKB-0.514
- INTERFERON_GAMMA_RESPONSE-0.466
- IL6_JAK_STAT3_SIGNALING-0.437
- INTERFERON_ALPHA_RESPONSE-0.419
- ALLOGRAFT_REJECTION-0.409
- HYPOXIA-0.403
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- INFLAMMATORY_RESPONSE-0.396
- KRAS_SIGNALING_UP-0.356
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_QRDT19KS | medulloblastoma | — | 0.897 |
| 2 | TCGA-FJ-A3ZF-01A-11R-A23N-07 | — | — | 0.882 |
| 3 | TCGA-CR-7374-01A-11R-2016-07 | — | — | 0.880 |
| 4 | TCGA-BB-4223-01A-01R-1436-07 | — | — | 0.876 |
| 5 | SRR12696768 | — | — | 0.875 |
| 6 | MDT-AP-0196 | Med | Medulloblastoma | 0.875 |
| 7 | BS_A14Z8BBK | medulloblastoma | — | 0.873 |
| 8 | BS_BA6AZWB3 | medulloblastoma | — | 0.872 |
| 9 | MNG214 | — | — | 0.869 |
| 10 | TCGA-LT-A5Z6-01A-11R-A28M-07 | — | — | 0.868 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.309 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.260 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.251 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.247 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.152 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.101 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.065 | Cobimetinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.043 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.021 | Inavolisib | — uncovered |