TCGA-CR-7374-01A-11R-2016-07
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.180
- G2M_CHECKPOINT+0.160
- SPERMATOGENESIS+0.140
- E2F_TARGETS+0.130
- BILE_ACID_METABOLISM+0.120
- UNFOLDED_PROTEIN_RESPONSE+0.100
- MITOTIC_SPINDLE+0.070
- WNT_BETA_CATENIN_SIGNALING-0.010
- KRAS_SIGNALING_DN-0.040
- PEROXISOME-0.080
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- INTERFERON_ALPHA_RESPONSE-0.490
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.490
- TNFA_SIGNALING_VIA_NFKB-0.480
- HYPOXIA-0.440
- INTERFERON_GAMMA_RESPONSE-0.430
- ANGIOGENESIS-0.420
- MYOGENESIS-0.420
- COAGULATION-0.410
- APICAL_JUNCTION-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-FJ-A3ZF-01A-11R-A23N-07 | — | — | 0.922 |
| 2 | SRR934766 | — | — | 0.908 |
| 3 | BS_QRDT19KS | medulloblastoma | — | 0.907 |
| 4 | BS_W311713R | medulloblastoma | — | 0.905 |
| 5 | BS_4W68NV3M | medulloblastoma | — | 0.902 |
| 6 | BS_61E80SD6 | medulloblastoma | — | 0.895 |
| 7 | a50c02ec-6ba9-4678-990d-6c74a8e9b7b5 | — | — | 0.894 |
| 8 | BS_KN92S7YQ | medulloblastoma | — | 0.891 |
| 9 | TCGA-LT-A5Z6-01A-11R-A28M-07 | — | — | 0.890 |
| 10 | BS_2SFTWNVE | medulloblastoma | — | 0.890 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.180 | Cobimetinib | — uncovered |
| G2M_CHECKPOINT | 0.160 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.140 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.130 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.120 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.100 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.070 | Inavolisib | — uncovered |