37e6146e-6fec-4160-822c-404a517610a8
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.200
- ANDROGEN_RESPONSE+0.100
- CHOLESTEROL_HOMEOSTASIS+0.100
- FATTY_ACID_METABOLISM+0.100
- HEDGEHOG_SIGNALING+0.100
- MTORC1_SIGNALING+0.100
- MYC_TARGETS_V1+0.100
- SPERMATOGENESIS+0.100
- APICAL_SURFACE+0.000
- APOPTOSIS+0.000
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.500
- INTERFERON_GAMMA_RESPONSE-0.500
- TNFA_SIGNALING_VIA_NFKB-0.500
- ALLOGRAFT_REJECTION-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- COMPLEMENT-0.300
- HYPOXIA-0.300
- IL2_STAT5_SIGNALING-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-CN-6992-01A-11R-1915-07 | — | — | 0.830 |
| 2 | SRR23303758 | — | — | 0.813 |
| 3 | SRR1072504 | GTEX | — | 0.809 |
| 4 | SRR658129 | GTEX | — | 0.808 |
| 5 | SRR1322163 | GTEX | — | 0.808 |
| 6 | MBCProject_0343_T1_RNA | — | B | 0.807 |
| 7 | SRR35579848 | — | B | 0.806 |
| 8 | TCGA-GV-A3JW-01A-11R-A20F-07 | — | — | 0.805 |
| 9 | DRR168589 | — | — | 0.800 |
| 10 | 8c7c9bb7-76e0-480c-a0de-bbf48fa398f4 | — | — | 0.800 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.100 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.100 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.100 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.100 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |