SRR1467882
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.420
- HEDGEHOG_SIGNALING+0.217
- MYOGENESIS+0.187
- SPERMATOGENESIS+0.153
- COAGULATION+0.147
- BILE_ACID_METABOLISM+0.108
- XENOBIOTIC_METABOLISM+0.096
- PANCREAS_BETA_CELLS+0.083
- ESTROGEN_RESPONSE_EARLY+0.067
- ESTROGEN_RESPONSE_LATE+0.065
Top 10 suppressed
- MYC_TARGETS_V1-0.520
- PROTEIN_SECRETION-0.480
- INTERFERON_ALPHA_RESPONSE-0.479
- E2F_TARGETS-0.463
- G2M_CHECKPOINT-0.442
- MTORC1_SIGNALING-0.420
- INTERFERON_GAMMA_RESPONSE-0.415
- ANDROGEN_RESPONSE-0.382
- IL6_JAK_STAT3_SIGNALING-0.374
- UNFOLDED_PROTEIN_RESPONSE-0.346
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1414833 | GTEX | — | 0.949 |
| 2 | SRR1406561 | GTEX | — | 0.944 |
| 3 | SRR1456950 | GTEX | — | 0.944 |
| 4 | SRR1486560 | GTEX | — | 0.940 |
| 5 | SRR1400997 | GTEX | — | 0.938 |
| 6 | SRR1396123 | GTEX | — | 0.938 |
| 7 | SRR1341277 | GTEX | — | 0.937 |
| 8 | SRR1354734 | GTEX | — | 0.929 |
| 9 | SRR1381632 | GTEX | — | 0.928 |
| 10 | SRR1445347 | GTEX | — | 0.924 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.420 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.217 | Inavolisib | — uncovered |
| MYOGENESIS | 0.187 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.153 | Inavolisib | — uncovered |
| COAGULATION | 0.147 | Binimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.108 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.096 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.083 | Cobimetinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.067 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.065 | Idelalisib | — uncovered |