SRR1385124
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.489
- MYOGENESIS+0.248
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.237
- FATTY_ACID_METABOLISM+0.146
- SPERMATOGENESIS+0.119
- KRAS_SIGNALING_DN+0.111
- ADIPOGENESIS+0.108
- HEDGEHOG_SIGNALING+0.067
- HEME_METABOLISM+0.062
- DNA_REPAIR+0.061
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.500
- TNFA_SIGNALING_VIA_NFKB-0.487
- G2M_CHECKPOINT-0.458
- INTERFERON_ALPHA_RESPONSE-0.442
- INFLAMMATORY_RESPONSE-0.441
- INTERFERON_GAMMA_RESPONSE-0.438
- ANGIOGENESIS-0.419
- ALLOGRAFT_REJECTION-0.409
- E2F_TARGETS-0.356
- NOTCH_SIGNALING-0.334
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657587 | GTEX | — | 0.964 |
| 2 | SRR1468381 | GTEX | — | 0.952 |
| 3 | SRR600560 | GTEX | — | 0.950 |
| 4 | SRR1353157 | GTEX | — | 0.944 |
| 5 | SRR1415895 | GTEX | — | 0.937 |
| 6 | SRR659899 | GTEX | — | 0.937 |
| 7 | SRR1315970 | GTEX | — | 0.927 |
| 8 | SRR1478077 | GTEX | — | 0.926 |
| 9 | SRR1357434 | GTEX | — | 0.923 |
| 10 | SRR1096966 | GTEX | — | 0.912 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.489 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.248 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.237 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.146 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.119 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.111 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.108 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.067 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.062 | Temsirolimus | — uncovered |
| DNA_REPAIR | 0.061 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.058 | Idelalisib | — uncovered |
| PEROXISOME | 0.042 | Idelalisib | — uncovered |