MNG1208
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.375
- KRAS_SIGNALING_DN+0.254
- SPERMATOGENESIS+0.232
- HEDGEHOG_SIGNALING+0.092
- INTERFERON_ALPHA_RESPONSE+0.074
- E2F_TARGETS+0.066
- G2M_CHECKPOINT+0.058
- APICAL_SURFACE+0.004
- KRAS_SIGNALING_UP-0.029
- ESTROGEN_RESPONSE_LATE-0.048
Top 10 suppressed
- ADIPOGENESIS-0.476
- TGF_BETA_SIGNALING-0.461
- UNFOLDED_PROTEIN_RESPONSE-0.446
- PROTEIN_SECRETION-0.432
- OXIDATIVE_PHOSPHORYLATION-0.425
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.417
- NOTCH_SIGNALING-0.407
- APOPTOSIS-0.400
- ANDROGEN_RESPONSE-0.392
- PI3K_AKT_MTOR_SIGNALING-0.389
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG598 | — | — | 0.903 |
| 2 | MNG1164 | — | — | 0.902 |
| 3 | MNG555 | — | — | 0.902 |
| 4 | MNG1131 | — | — | 0.902 |
| 5 | SRR13311179 | — | — | 0.898 |
| 6 | SRR1797291 | — | cohortSC | 0.895 |
| 7 | SRR12696788 | — | — | 0.891 |
| 8 | msclc569389_S35.txt | — | cohortMD1 | 0.891 |
| 9 | MDT-AP-3189 | Med | Medulloblastoma | 0.887 |
| 10 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.887 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.375 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.254 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.232 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.092 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.074 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.066 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.058 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.004 | Temsirolimus | — uncovered |