MNG1164
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.376
- SPERMATOGENESIS+0.318
- PANCREAS_BETA_CELLS+0.300
- HEDGEHOG_SIGNALING+0.101
- ESTROGEN_RESPONSE_LATE+0.058
- COAGULATION-0.023
- KRAS_SIGNALING_UP-0.027
- MYOGENESIS-0.040
- APICAL_JUNCTION-0.045
- ESTROGEN_RESPONSE_EARLY-0.063
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.595
- PROTEIN_SECRETION-0.578
- MYC_TARGETS_V1-0.562
- UNFOLDED_PROTEIN_RESPONSE-0.476
- ADIPOGENESIS-0.474
- TGF_BETA_SIGNALING-0.473
- ANDROGEN_RESPONSE-0.472
- FATTY_ACID_METABOLISM-0.471
- MTORC1_SIGNALING-0.468
- DNA_REPAIR-0.448
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1366141 | GTEX | — | 0.967 |
| 2 | MNG598 | — | — | 0.963 |
| 3 | MNG555 | — | — | 0.962 |
| 4 | MNG1003 | — | — | 0.959 |
| 5 | MNG1131 | — | — | 0.959 |
| 6 | MNG597 | — | — | 0.953 |
| 7 | msclc569389_S35.txt | — | cohortMD1 | 0.952 |
| 8 | SRR1323130 | GTEX | — | 0.952 |
| 9 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.951 |
| 10 | SRR12696761 | — | — | 0.947 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.376 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.318 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.101 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.058 | Idelalisib | — uncovered |