SRR1409899
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.150
- PROTEIN_SECRETION+0.103
- PI3K_AKT_MTOR_SIGNALING+0.061
- MITOTIC_SPINDLE+0.045
- HEME_METABOLISM+0.036
- OXIDATIVE_PHOSPHORYLATION+0.011
- FATTY_ACID_METABOLISM+0.009
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.007
- MYOGENESIS-0.005
- SPERMATOGENESIS-0.006
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.507
- INTERFERON_GAMMA_RESPONSE-0.447
- ALLOGRAFT_REJECTION-0.438
- INFLAMMATORY_RESPONSE-0.436
- TNFA_SIGNALING_VIA_NFKB-0.407
- ANGIOGENESIS-0.395
- TGF_BETA_SIGNALING-0.378
- COAGULATION-0.363
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.361
- APOPTOSIS-0.355
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1362060 | GTEX | — | 0.966 |
| 2 | SRR613366 | GTEX | — | 0.964 |
| 3 | SRR657915 | GTEX | — | 0.964 |
| 4 | SRR612419 | GTEX | — | 0.955 |
| 5 | SRR659412 | GTEX | — | 0.950 |
| 6 | SRR1417981 | GTEX | — | 0.950 |
| 7 | SRR1327811 | GTEX | — | 0.950 |
| 8 | SRR1473185 | GTEX | — | 0.950 |
| 9 | SRR820468 | GTEX | — | 0.949 |
| 10 | SRR1394450 | GTEX | — | 0.949 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.150 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.103 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.061 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.045 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.036 | Temsirolimus | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.011 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.009 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.007 | Inavolisib | — uncovered |