MNG1113
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- P53_PATHWAY+0.151
- DNA_REPAIR+0.106
- MYOGENESIS+0.092
- APOPTOSIS+0.035
- COAGULATION+0.033
- PEROXISOME+0.022
- OXIDATIVE_PHOSPHORYLATION+0.019
- TGF_BETA_SIGNALING+0.019
- ALLOGRAFT_REJECTION+0.011
- IL6_JAK_STAT3_SIGNALING-0.001
Top 10 suppressed
- MTORC1_SIGNALING-0.469
- ANGIOGENESIS-0.434
- G2M_CHECKPOINT-0.431
- PROTEIN_SECRETION-0.429
- ANDROGEN_RESPONSE-0.421
- E2F_TARGETS-0.344
- KRAS_SIGNALING_UP-0.323
- MITOTIC_SPINDLE-0.271
- UNFOLDED_PROTEIN_RESPONSE-0.265
- GLYCOLYSIS-0.259
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1250 | — | — | 0.854 |
| 2 | TCGA-EW-A423-01A-11R-A24H-07 | — | B | 0.808 |
| 3 | MNG656 | — | — | 0.797 |
| 4 | BS_A87NPZAP | Med | Medulloblastoma | 0.797 |
| 5 | MNG1087 | — | — | 0.795 |
| 6 | MNG193 | — | — | 0.787 |
| 7 | MNG1107 | — | — | 0.780 |
| 8 | TCGA-OL-A5DA-01A-11R-A27Q-07 | — | B | 0.780 |
| 9 | SRR1313120 | — | A | 0.775 |
| 10 | b6a7e87e-2674-4a48-a3c2-c8a9806762b5 | — | — | 0.771 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| P53_PATHWAY | 0.151 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.106 | Idelalisib | — uncovered |
| MYOGENESIS | 0.092 | Inavolisib | — uncovered |
| APOPTOSIS | 0.035 | Idelalisib | — uncovered |
| COAGULATION | 0.033 | Binimetinib | — uncovered |
| PEROXISOME | 0.022 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.019 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.019 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.011 | Idelalisib | — uncovered |