SRR1313120

— · A

b4b732de-0489-53fc-b8bf-ce9b1bc5944d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: A
subtype: A

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

MYOGENESIS+0.180
BILE_ACID_METABOLISM+0.060
UV_RESPONSE_DN+0.050
ADIPOGENESIS+0.030
XENOBIOTIC_METABOLISM+0.000
TGF_BETA_SIGNALING-0.040
FATTY_ACID_METABOLISM-0.050
HEDGEHOG_SIGNALING-0.060
APICAL_JUNCTION-0.090
IL6_JAK_STAT3_SIGNALING-0.110

Top 10 suppressed

E2F_TARGETS-0.670
MYC_TARGETS_V1-0.670
G2M_CHECKPOINT-0.580
MTORC1_SIGNALING-0.570
MYC_TARGETS_V2-0.540
UNFOLDED_PROTEIN_RESPONSE-0.440
ANDROGEN_RESPONSE-0.390
CHOLESTEROL_HOMEOSTASIS-0.390
PROTEIN_SECRETION-0.380
OXIDATIVE_PHOSPHORYLATION-0.350

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR1313099 breast-umap@18	—	A	0.924
2	SRR8526730 lung-landscapes@6	—	cohortA1	0.901
3	BS_A87NPZAP medullo-epn-umap@date-based	Med	Medulloblastoma	0.889
4	C3N-00293 lung-landscapes@6	—	cohortA1	0.889
5	SRR2016932 head-neck@1	—	—	0.884
6	TCGA-A7-A13G-01B-04R-A22O-07 breast-umap@18	—	D	0.880
7	SRR1313097 breast-umap@18	—	A	0.879
8	TCGA-55-A4DG-01A-11R-A24H-07 lung-landscapes@6	—	cohortA1	0.879
9	b03ebc32.a177.44c7.8b02.fcd6560712f2 lung-landscapes@6	—	cohortA1	0.876
10	SRR25617883 breast-umap@18	—	B	0.874

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
MYOGENESIS	0.180	Inavolisib	— uncovered
BILE_ACID_METABOLISM	0.060	Inavolisib	— uncovered
UV_RESPONSE_DN	0.050	Inavolisib	— uncovered
ADIPOGENESIS	0.030	Inavolisib	— uncovered