Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BA-5559-01A-01R-1514-07

c5693583-59d3-58b4-9464-e2fd527b1f50

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.475570776
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.390
  • E2F_TARGETS+0.280
  • MYOGENESIS+0.260
  • G2M_CHECKPOINT+0.240
  • INTERFERON_GAMMA_RESPONSE+0.170
  • IL6_JAK_STAT3_SIGNALING+0.160
  • MITOTIC_SPINDLE+0.160
  • SPERMATOGENESIS+0.150
  • KRAS_SIGNALING_DN+0.040
  • WNT_BETA_CATENIN_SIGNALING+0.010

Top 10 suppressed

  • MYC_TARGETS_V2-0.540
  • MYC_TARGETS_V1-0.490
  • OXIDATIVE_PHOSPHORYLATION-0.470
  • MTORC1_SIGNALING-0.460
  • UNFOLDED_PROTEIN_RESPONSE-0.460
  • CHOLESTEROL_HOMEOSTASIS-0.440
  • GLYCOLYSIS-0.430
  • HYPOXIA-0.380
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.370
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.340

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-85-A4PA-01A-11R-A24Z-07
lung-landscapes@6
cohortMD20.885
2DRR168597
bladder-landscape@3
0.868
3SRR602753
brain-umap@2
GTEX0.845
4SRR2932833
head-neck@1
0.834
5SRR598533
brain-umap@2
GTEX0.833
6MNG83
mng-umap@100
0.830
7SRR5088892
melanoma-umap@29
0.829
8X65f5effa.07f7.4ed3.9e0a.3a0d9d451474
lung-landscapes@6
cohortA10.821
9TCGA-QK-A6IF-01A-11R-A31N-07
head-neck@1
0.816
10AUR-AG0J-TTP1-A-1-0-R-A741-41
breast-umap@18
D0.814

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.390Idelalisib— uncovered
E2F_TARGETS0.280Inavolisib— uncovered
MYOGENESIS0.260Inavolisib— uncovered
G2M_CHECKPOINT0.240Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.170Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.160Inavolisib— uncovered
MITOTIC_SPINDLE0.160Inavolisib— uncovered
SPERMATOGENESIS0.150Inavolisib— uncovered
KRAS_SIGNALING_DN0.040Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.010Inavolisib— uncovered