SRR1352415
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.125
- DNA_REPAIR+0.107
- MITOTIC_SPINDLE+0.049
- MYC_TARGETS_V2+0.048
- SPERMATOGENESIS+0.037
- UNFOLDED_PROTEIN_RESPONSE+0.020
- OXIDATIVE_PHOSPHORYLATION+0.003
- MYC_TARGETS_V1-0.017
- PROTEIN_SECRETION-0.024
- PI3K_AKT_MTOR_SIGNALING-0.034
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.603
- TNFA_SIGNALING_VIA_NFKB-0.526
- INTERFERON_GAMMA_RESPONSE-0.524
- INFLAMMATORY_RESPONSE-0.514
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.492
- IL6_JAK_STAT3_SIGNALING-0.472
- ALLOGRAFT_REJECTION-0.462
- ANGIOGENESIS-0.459
- APOPTOSIS-0.429
- COMPLEMENT-0.425
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1361714 | GTEX | — | 0.988 |
| 2 | SRR1464305 | GTEX | — | 0.987 |
| 3 | SRR1319672 | GTEX | — | 0.984 |
| 4 | SRR1490568 | GTEX | — | 0.984 |
| 5 | SRR1441224 | GTEX | — | 0.984 |
| 6 | SRR1356204 | GTEX | — | 0.984 |
| 7 | SRR1419675 | GTEX | — | 0.984 |
| 8 | SRR807657 | GTEX | — | 0.984 |
| 9 | SRR1456531 | GTEX | — | 0.983 |
| 10 | SRR1499982 | GTEX | — | 0.982 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.125 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.107 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.049 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.048 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.037 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.020 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.003 | Remibrutinib | — uncovered |