SRR25617910
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.330
- SPERMATOGENESIS+0.290
- E2F_TARGETS+0.200
- INTERFERON_ALPHA_RESPONSE+0.180
- KRAS_SIGNALING_DN+0.110
- BILE_ACID_METABOLISM-0.010
- INTERFERON_GAMMA_RESPONSE-0.040
- G2M_CHECKPOINT-0.110
- XENOBIOTIC_METABOLISM-0.110
- HEME_METABOLISM-0.150
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.540
- HYPOXIA-0.470
- TNFA_SIGNALING_VIA_NFKB-0.470
- NOTCH_SIGNALING-0.460
- UV_RESPONSE_DN-0.460
- CHOLESTEROL_HOMEOSTASIS-0.430
- P53_PATHWAY-0.420
- TGF_BETA_SIGNALING-0.420
- APOPTOSIS-0.360
- ESTROGEN_RESPONSE_EARLY-0.360
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR25617833 | — | B | 0.932 |
| 2 | SRR25617852 | — | B | 0.924 |
| 3 | SRR1313096 | — | B | 0.923 |
| 4 | SRR33346946 | — | — | 0.912 |
| 5 | SRR26320083 | — | — | 0.892 |
| 6 | SRR934771 | — | — | 0.892 |
| 7 | SRR11296798 | — | — | 0.890 |
| 8 | SRR934972 | — | — | 0.876 |
| 9 | SRR8943038 | — | — | 0.873 |
| 10 | MNG1208 | — | — | 0.871 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.330 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.290 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.200 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.180 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.110 | Remibrutinib | — uncovered |