SRR1361736
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.139
- DNA_REPAIR+0.087
- MYOGENESIS+0.078
- PROTEIN_SECRETION+0.072
- MITOTIC_SPINDLE+0.055
- SPERMATOGENESIS+0.036
- UNFOLDED_PROTEIN_RESPONSE-0.022
- APICAL_JUNCTION-0.031
- HEME_METABOLISM-0.038
- MYC_TARGETS_V2-0.038
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.634
- INFLAMMATORY_RESPONSE-0.536
- IL6_JAK_STAT3_SIGNALING-0.531
- INTERFERON_GAMMA_RESPONSE-0.525
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.483
- TNFA_SIGNALING_VIA_NFKB-0.479
- ALLOGRAFT_REJECTION-0.468
- COAGULATION-0.453
- ANGIOGENESIS-0.452
- KRAS_SIGNALING_UP-0.438
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1490568 | GTEX | — | 0.985 |
| 2 | SRR1359367 | GTEX | — | 0.983 |
| 3 | SRR1464305 | GTEX | — | 0.983 |
| 4 | SRR1479239 | GTEX | — | 0.983 |
| 5 | SRR1319672 | GTEX | — | 0.983 |
| 6 | SRR1441224 | GTEX | — | 0.979 |
| 7 | SRR1401062 | GTEX | — | 0.978 |
| 8 | SRR1352415 | GTEX | — | 0.977 |
| 9 | SRR1401552 | GTEX | — | 0.976 |
| 10 | SRR1327811 | GTEX | — | 0.976 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.139 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.087 | Idelalisib | — uncovered |
| MYOGENESIS | 0.078 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.072 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.055 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.036 | Inavolisib | — uncovered |